Articles are definitive, full accounts of significant studies.
Manuscripts can be submitted as Articles, Perspectives, or Drug Annotations. The Journal publishes 24 issues per year on the second and fourth Thursdays of each month.
The Journal does not publish papers based on studies with crude extracts.
Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.
This may include design, synthesis, and evaluation of novel types of prodrugs.
Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds.
Substantially novel computational chemistry methods with demonstrated utility for the identification, optimization, or target interaction analysis of bioactive molecules.
CHEM C3000 CHEMICALS NOT INCLUDED SERIES
Computational studies that analyze the SAR of compound series of general interest and lead to experimental studies or analysis of other available chemical and/or biological data that substantially advance medicinal chemistry knowledge.
Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.
Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.
Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be considered for publication.
Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR).
Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.
Some specific areas that are appropriate include the following. The primary objective of the Journal is to publish studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action. The Journal of Medicinal Chemistry(Journal) invites original research contributions dealing with chemical-biological relationships. Authors may suggest Associate Editor(s) to handle your manuscript, however, due to manuscript workload, the desired Editor may not be assigned. elemental analysis) that were used need to be indicated. Alternatively, other methods of purity determination (e.g. The letter should also contain the Journal purity statement (which should also be stated in the general experimental section of the manuscript) that “All compounds are >95% pure by HPLC analysis.” HPLC traces should be included for all compounds that have in vivo data described in the manuscript or, if no in vivo data, a representative number of HPLC traces of compounds described with in vitro data in the SAR tables (HPLC traces should be in the Supporting Information, SI). Submissions should be accompanied by a standard cover letter that should include the title of the manuscript, a short description of the research, and why it is appropriate for JMC. The journal no longer requires the Author Submission Checklist for Articles and Drug Annotations. Please review the Editorial “Simplifying Submission Requirements for the Journal of Medicinal Chemistry” for an overview of recent changes. Manuscript Submission Requirements Checklist Resolution | Size | Color | Types of Graphics | Table of Contents (TOC)/Abstract Graphic | Figures | Charts | Tables | Schemes | Chemical Structures | Cover Art | Web Enhanced Objects (WEO)
Journal of the American Society for Mass Spectrometry.
Journal of the American Chemical Society.
The Journal of Physical Chemistry Letters.
- The Journal of Physical and Colloid Chemistry.
Journal of Chemical Theory and Computation.
- Journal of Chemical Information and Computer Sciences.
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